White Matter Lesions and Glial Activation in a Novel Mouse Model of Chronic Cerebral Hypoperfusion
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چکیده
منابع مشابه
White matter lesions and glial activation in a novel mouse model of chronic cerebral hypoperfusion.
BACKGROUND AND PURPOSE Cerebrovascular white matter (WM) lesions are closely associated with cognitive impairment and gait disorders in the elderly. We have successfully established a mouse model of chronic cerebral hypoperfusion that may provide new strategies for the molecular analysis of cerebrovascular WM lesions. METHODS Adult C57Bl/6 male mice were subjected to bilateral common carotid ...
متن کاملCharacterization of White Matter Injury in a Rat Model of Chronic Cerebral Hypoperfusion.
BACKGROUND AND PURPOSE Chronic cerebral hypoperfusion can lead to ischemic white matter injury resulting in vascular dementia. To characterize white matter injury in vascular dementia, we investigated disintegration of diverse white matter components using a rat model of chronic cerebral hypoperfusion. METHODS Chronic cerebral hypoperfusion was modeled in Wistar rats by permanent occlusion of...
متن کاملMatrix metalloproteinase-2 plays a critical role in the pathogenesis of white matter lesions after chronic cerebral hypoperfusion in rodents.
BACKGROUND AND PURPOSE Cerebrovascular white matter (WM) lesions contribute to cognitive impairment and motor dysfunction in the elderly. A disruption of the blood-brain barrier (BBB) is believed to be a critical early event leading to these WM lesions. Previous studies have suggested the involvement of matrix metalloproteinase-2 (MMP-2) in BBB disruptions and the upregulation of MMP-2 after ch...
متن کاملLesions After Chronic Cerebral Hypoperfusion in Rodents Matrix Metalloproteinase-2 Plays a Critical Role in the Pathogenesis of White Matter
Kayoko Nakaji, Masafumi Ihara, Chiaki Takahashi, Shigeyoshi Itohara, Makoto Noda, Ryosuke Lesions After Chronic Cerebral Hypoperfusion in Rodents Matrix Metalloproteinase-2 Plays a Critical Role in the Pathogenesis of White Matter Print ISSN: 0039-2499. Online ISSN: 1524-4628 Copyright © 2006 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7...
متن کاملCilostazol protects against brain white matter damage and cognitive impairment in a rat model of chronic cerebral hypoperfusion.
BACKGROUND AND PURPOSE White matter lesions contribute to cognitive impairment in poststroke patients. The present study was designed to assess the neuroprotective mechanisms of cilostazol, a potent inhibitor of type III phosphodiesterase, through signaling pathways that lead to activation of transcription factor cAMP-responsive element binding protein (CREB) phosphorylation using rat chronic c...
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ژورنال
عنوان ژورنال: Stroke
سال: 2004
ISSN: 0039-2499,1524-4628
DOI: 10.1161/01.str.0000143725.19053.60